This guide presents the top ten prompts designed for leaders utilizing Microsoft Copilot, a conversational AI tool aimed at enhancing productivity and decision-making. It begins by defining what a prompt is and outlines its key components: Goal, Context, Expectations, and Source, which are essential for crafting effective prompts. The document emphasizes the importance of privacy and security, explaining that Copilot does not learn from individual interactions but utilizes a vast array of pre-existing data to provide accurate responses. It further discusses the integration of organizational data, which allows Copilot to tailor responses based on the user's context. The guide highlights various use cases for leadership roles, detailing the goals and challenges faced by leaders today. It underscores the necessity for leaders to ask the right questions to unlock insights and improve decision-making. The document concludes with specific prompts that can assist leaders in meeting preparation, stakeholder communication, and strategic planning.