This guide presents a comprehensive examination of the current state of diversity in clinical trials, addressing health disparities and the need for increased representation among trial participants. The document aggregates insights from various international experts in the field, including members of Abbott’s Diversity in Research Medical Advisory Board, to provide an informed perspective on the challenges and opportunities within clinical trial diversity. The focus includes understanding historical underrepresentation and the implications for diverse patient populations, as well as identifying barriers to participation such as lack of trust, access, and transparency. It outlines actionable strategies for stakeholders, including partnerships with community organizations and universities, to promote equitable representation in clinical research. The intention is to inspire organizations to invest in diverse clinical trials and adapt to evolving best practices in the field. By leveraging community engagement, education, and collaboration, the document aims to foster systemic change in how clinical trials are conducted and who they serve.