This document is a guide that outlines the Pre-Startup Safety Review (PSSR) process, which is a critical assessment conducted prior to the launch of new or modified processes, equipment, or facilities. The PSSR aims to identify potential hazards and ensure compliance with industry regulations and safety standards across various sectors, including manufacturing, oil and gas, pharmaceuticals, mining, and chemical processing. The checklist provided in the guide details essential steps such as verifying project documentation, ensuring equipment readiness, and confirming personnel training. It emphasizes the importance of mechanical and electrical integrity checks, environmental compliance, and process safety analysis. The guide also includes procedures for pre-startup testing and validation, along with a final review and sign-off process to certify compliance. By following this structured approach, organizations can mitigate risks, enhance safety, and maintain operational readiness.