Clinical Management Guidelines for MSH6 Variants

This guide provides an overview of clinical management guidelines for patients with pathogenic or likely pathogenic variants in the MSH6 gene. It outlines screening and surgical considerations for various cancers, including colorectal, endometrial, ovarian, and others, based on recommendations from the National Comprehensive Cancer Network (NCCN). The document emphasizes the importance of individualized treatment plans and consultation between patients and healthcare providers.