Clinical Management Guidelines for Tuberous Sclerosis Complex

This guide outlines clinical management guidelines for patients with a positive test result for a TSC1 or TSC2 gene mutation. It references the Updated International Tuberous Sclerosis Complex Diagnostic Criteria and Surveillance and Management Recommendations for detailed medical management guidelines. The document emphasizes the importance of clinical correlation with the patient's medical history, treatments, and family history, which may influence management decisions. It details various surveillance and surgical considerations for different organs affected by tuberous sclerosis complex (TSC), including the brain, kidneys, lungs, skin, heart, and eyes. The guide specifies the frequency of assessments and the age to start various evaluations. Additionally, it discusses the implications of TSC1 mutations, including cancer risks and the importance of family testing. The document encourages discussions between patients and healthcare providers to tailor management plans according to individual needs and circumstances.