BOOST Technology for Analyzing Whole Blood Elements

This technical report presents a method for accurately quantifying the metallic profile in whole blood using the PlasmaQuant MS Q equipped with BOOST technology. The objective is to achieve low limits of detection (LOD) for elements like chromium, which are often affected by interferences in complex biological matrices. The report details the challenges of analyzing whole blood due to its solid and liquid components and the necessity of precise sample preparation methods. It outlines the use of inductively coupled plasma mass spectrometry (ICP-MS) for this analysis, emphasizing the importance of addressing polyatomic interferences that can skew results. The methodology section describes the equipment setup, sample preparation, and calibration processes, ensuring robust and accurate measurements. Results indicate that the method can effectively measure trace concentrations of various elements in whole blood, demonstrating the efficacy of BOOST technology in enhancing sensitivity and detection limits. The findings support the method's applicability for routine analysis in clinical settings.