This guide provides an overview of the Toxic Substances Control Act (TSCA) and its implications for chemical compliance in the United States. It outlines the history and evolution of TSCA, including the updates made by the Frank R. Lautenberg Chemical Safety for the 21st Century Act in 2016. The document details the restrictions imposed under TSCA Section 6, particularly concerning five persistent, bioaccumulative, and toxic (PBT) substances, and the obligations placed on companies operating in the U.S. The guide emphasizes the importance of documentation and communication regarding restricted substances in products and supply chains. It also addresses compliance challenges, enforcement measures, and the potential for supply chain disruptions due to the new regulations. Companies are advised to evaluate their supply chains proactively to mitigate risks associated with these chemical restrictions and ensure adherence to TSCA requirements.