Recommended Drug Modifications for CKD and AKI

This guide provides recommendations for drug modifications in patients with Chronic Kidney Disease (CKD) and Acute Kidney Injury (AKI). It outlines specific medications that require dosage adjustments or temporary cessation based on the patient's kidney function. The document emphasizes the importance of consulting with a pharmacist or specialist for detailed medication inquiries. It lists various medications, including NSAIDs, ACE inhibitors, and diuretics, detailing their pathophysiology, recommendations for use in CKD, and whether they should be held during AKI. For instance, NSAIDs should be used with caution in CKD and held during critical illness. The guide also highlights the need for dose reductions in medications like opioids and pregabalin due to potential accumulation and adverse effects. Overall, the guide serves as a resource for primary care practitioners to ensure safe medication management in patients with compromised kidney function.