Histidine-Tagged Protein Purification for Vaccines

This case study explores the purification of His6-tagged SARS-CoV-2 receptor binding domain (rRBD) using Nuvia IMAC Resin. It highlights the challenges of achieving high yield and purity in viral protein production for vaccines, emphasizing the efficiency and adaptability of the purification process. The study demonstrates a significant yield of 21.1 mg rRBD/l cell culture supernatant with 82% recovery, showcasing Nuvia IMAC Resin's effectiveness in vaccine research and development.