Clinical and Economic Compendium of Intravascular Ultrasound Evidence

This literature review report summarizes the global evidence on the use of intravascular ultrasound (IVUS) as an adjunct to angiography for patients undergoing percutaneous coronary intervention (PCI). The report identifies evidence through a targeted literature review, focusing on clinical trials, real-world studies, and economic evaluations published from January 2016 to January 2025. The clinical review includes comparative studies of IVUS plus angiography versus angiography alone, involving over 300 patients in the IVUS arm. The economic review encompasses cost-effectiveness analyses and budget impact models identified from various databases. Key guideline recommendations and evidence from randomized trials, real-world studies, and economic evaluations are summarized, with comprehensive outcome data available in the appendices. The report aims to provide a thorough understanding of the clinical and economic implications of IVUS in PCI procedures.