Clinical Evidence for Endoscopic Sleeve Gastroplasty Procedures

This technical report presents clinical evidence regarding Endoscopic Sleeve Gastroplasty (ESG) as a primary endobariatric procedure for obesity management. It outlines the efficacy and safety of ESG, emphasizing its role as a minimally invasive alternative to traditional surgical methods. The report includes a systematic literature review and meta-analysis, detailing outcomes from numerous studies involving over 15,000 patients. It highlights significant weight loss results, with mean excess weight loss (EWL) and total body weight loss (TBWL) reported at various follow-up intervals. Additionally, it discusses findings from a prospective multicenter randomized trial comparing ESG with lifestyle modifications alone, indicating that ESG can lead to substantial weight loss and improvements in metabolic comorbidities. The report also includes a position statement from the IFSO Bariatric Endoscopy Committee, reinforcing the clinical relevance of ESG in treating obesity, particularly for patients who are not candidates for metabolic and bariatric surgery. Overall, the report provides comprehensive insights into the safety and efficacy of ESG.