Evaluation of TXRF Spectrometer for Blood Analysis

This report evaluates the suitability of the TXRF spectrometer S2 PICOFOX for blood analysis. It consists of two main parts. The first part describes the analysis of essential and toxic trace elements in blood serum and whole blood. It outlines the challenges of analyzing these elements due to the high organic matrix content and the need for time-consuming sample preparation methods. The report discusses the feasibility of using TXRF spectroscopy for blood analysis without extensive preparation, highlighting the method's effectiveness in determining essential elements like Fe, Cu, and Zn, as well as toxic metals such as Pb and Hg. The second part focuses on the analysis of platinum (Pt) concentration in blood samples from cancer patients undergoing chemotherapy. It details the sample preparation and quantification methods used, emphasizing the importance of monitoring Pt levels due to its toxicity and the variability in kidney function among patients. The report concludes that TXRF analysis is a versatile tool for trace element analysis in blood samples.