This guide discusses the transition of health plans from external post-pay audits to internal prepay cost avoidance strategies. It highlights the significant waste in U.S. healthcare spending, with a focus on administrative complexity contributing to excess costs. The document outlines the benefits of prospective claims validation over traditional post-payment audits, emphasizing the importance of reducing administrative churn and improving provider relationships. It identifies challenges that health plans face in executing prepay goals, including siloed departments, provider abrasion risks, limited technology, and over-reliance on vendors. The guide presents insights into how advanced technology can facilitate a more sophisticated approach to payment integrity, allowing health plans to maximize avoidance and recoveries while minimizing costs. It also discusses the role of primary editors in claims processing and the limitations they present, advocating for a more integrated and proactive claims validation process to enhance operational efficiency and reduce overpayment risks.