POSEIDON Platform Enhancements for Cancer Care

This case study details the implementation and impact of City of Hope's POSEIDON platform, a cloud-based precision oncology system designed to enhance cancer care through advanced biomarker analysis. The platform utilizes the DNAnexus technology stack to streamline the analysis of breast cancer biomarkers across multiple clinical trial sites. Key features include a robust biomarker protocol for uniform analysis, a secure environment that complies with regulations, and a significant reduction in analysis time from three days to under two hours. The research team, led by Dr. Andrea Bild and Dr. Aritro Nath, developed machine learning models to identify and validate biomarkers for endocrine therapy and mTOR inhibitors, facilitating informed treatment decisions. The POSEIDON platform supports drug development, clinical decision-making, and the generation of reports for clinical trials. The successful implementation of this system has opened opportunities for collaboration with external researchers, further advancing personalized cancer care.