This document is a solution brief that outlines the critical importance of securing AI data centers, which are essential to national security and defense due to the sensitive data they process. It describes the unique challenges faced in securing these infrastructures, including the risks associated with high-performance computing (HPC) as identified by NIST SP 800-223. The text details various risks such as attacks on hardware components, supply chain vulnerabilities, and challenges in validating firmware on shared compute infrastructure. Additionally, it presents security practices recommended by OpenAI for enhancing AI infrastructure security. The brief emphasizes Eclypsium's proactive security solutions, which include continuous monitoring, vulnerability management, and threat detection for AI servers and GPUs. It highlights the platform's capabilities in managing and securing critical assets, ensuring firmware integrity, and providing comprehensive inventory analysis of components within AI data centers. The document concludes by noting the ease of deployment and broad support for various AI technologies.