Study on Biomarkers for Asthma Exacerbations

This study is a non-interventional research article that investigates the correlation between fractional exhaled nitric oxide (FeNO) and blood eosinophils as biomarkers in predicting asthma exacerbations. The objective is to assess how these biomarkers relate to the frequency of severe asthma exacerbations and the associated healthcare resource utilization. The study involves a cohort of patients with asthma who meet specific inclusion criteria, including a history of asthma and relevant biomarker measurements. The research is structured into phases, with the first two phases focusing on comparing exacerbation rates among different biomarker levels before and after FeNO measurement. The third phase evaluates quality of life data, while the fourth phase examines the consistency of biomarker levels over time. The study utilizes a bespoke dataset from the Optimum Patient Care Research Database and aims to provide insights into the management of severe asthma through the identification of patients at higher risk of exacerbations.