This document is a guide that outlines key regulatory developments in the UK payments sector anticipated for 2025. It highlights the evolving landscape of payments regulation following significant changes in the previous year and emphasizes the importance of the National Payments Vision (NPV) as a framework for future regulatory efforts. The guide details the expected changes in supervisory priorities and the regulatory framework, including the review of existing Payment Services Regulations and Electronic Money Regulations. It discusses the implications of new legislation related to Buy-Now, Pay-Later schemes, digital wallets, and stablecoins. Additionally, the document addresses the integration of the Payments Systems Regulator into the Financial Conduct Authority, aiming to streamline regulatory processes. The guide also covers the anticipated focus on financial crime and consumer protection, as well as the role of innovation and technology in shaping the regulatory environment. Overall, it serves as a comprehensive resource for payment service providers to navigate the regulatory landscape in 2025.