Performance Evaluation of Genius AI Detection Software v2.0

This technical report provides a detailed evaluation of the performance of Genius AI Detection Software version 2.0, comparing it with the earlier version of the software. The report outlines the improvements made in the cancer detection algorithm for 3D breast tomosynthesis images, highlighting the enhanced specificity that reduces false positive marks. The study utilized fROC analysis to assess the performance of both versions using a sequestered dataset of Hologic’s 3D breast tomosynthesis exams. Key metrics were analyzed across different acquisition modes and lesion types. The report also evaluates the CC-MLO Correlation software, detailing its accuracy in correlating marks between standard screening views. The findings indicate that Genius AI Detection Software 2.0 maintains high sensitivity while significantly reducing false positive rates and improving specificity. The report concludes with performance metrics that confirm the advancements in the new version, emphasizing the accuracy of the CC-MLO Correlation algorithm in both malignant and negative cases.