This guide outlines the framework for adopting agentic commerce, focusing on how merchants and ecommerce leaders can leverage AI to drive growth while ensuring trust and safety. It describes the transformation in digital commerce where AI-powered agents streamline the customer journey by collapsing traditional sales funnels into single interactions. The guide emphasizes the importance of merchants being prepared for this shift, detailing practical steps for building readiness, including enhancing discoverability, reliability, and governance. It also discusses the challenges of ensuring that both brands and agents can be trusted, highlighting the need for machine-readable catalogs and fast APIs. The document presents insights into the current state of agentic commerce, noting the rapid increase in consumer adoption of AI-driven shopping assistants and the implications for merchants. It concludes with a framework for readiness, emphasizing the need for businesses to adapt to the evolving landscape of digital commerce driven by AI agents.