This white paper discusses the Trust Spanning Protocol (TSP) as a foundational element for enhancing trust in AI interactions. Authored by members of the AI and Human Trust Task Force, the document outlines the necessity of integrating TSP into AI ecosystems to address challenges related to information trust. It describes TSP as a low-level protocol that facilitates secure message exchanges between AI systems, emphasizing its role in establishing authenticity and privacy. The paper also examines the rapid advancements in AI technology and the implications for trustworthiness, highlighting the need for robust frameworks that incorporate social, technical, and psychological dimensions of trust. Additionally, it addresses the responsibilities of various stakeholders, including AI model developers and service deployers, in ensuring the safe and ethical deployment of AI systems. The document serves as a comprehensive guide for understanding the interplay between decentralized trust technologies and AI, aiming to foster greater confidence in AI applications across diverse sectors.