ToMMo Project Achieves 100,000 Genomes Milestone

This technical report discusses the achievements of the Tohoku Medical Megabank Organization (ToMMo) in sequencing genomic data from 100,000 participants following the Great East Japan Earthquake. The project aims to enhance medical research and support the redevelopment of the affected region. It includes two main studies: the Community-Based Cohort and the Birth and Three-Generation Cohort, which collectively recruited over 160,000 individuals. The report details the methodologies used, including health assessments and the collection of various biological samples. It highlights the project's reliance on Illumina technology and its goal of integrating genomic data with health records to advance precision medicine. The findings are expected to contribute to understanding genetic factors influencing health, particularly regarding dementia and rare genetic diseases. The report emphasizes the importance of this initiative in creating a comprehensive dataset that reflects human genetic diversity, especially for the Japanese population, and its potential impact on drug discovery and personalized care.