Adipose Derived Stromal Vascular Fraction Cells Therapy in Hemophilic Arthropathy

This case report details the application of adipose-derived stromal vascular fraction (SVF) cells therapy in a 34-year-old male patient diagnosed with hemophilia B and grade 4 hemophilic knee arthrosis. The report outlines the background of SVF, which is derived from adipose tissue and is known for its anti-inflammatory properties and potential in tissue repair. The patient, who had not benefited from conventional treatments, underwent intra-articular SVF therapy after thorough pre-operative assessments. The procedure involved the collection and processing of adipose tissue, followed by the administration of SVF into the affected knee. Clinical evaluations, including the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and six-minute walk distance (6MWD), demonstrated significant improvements in pain and mobility over a one-year follow-up period. The findings suggest that intra-articular SVF treatment may be a viable option for managing hemophilic arthropathy that is unresponsive to conservative treatments, highlighting its minimally invasive nature and low side effects.