Comparison of Non-Hormonal Treatments for Genitourinary Syndrome

This study is a prospective research article that compares the efficacy of non-hormonal alternatives, specifically vaginal hyaluronic acid and oral probiotics, against vaginal estradiol, a standard therapy for the treatment of genitourinary syndrome of menopause (GSM). Conducted in the Obstetrics and Gynecology Clinic, the study involved women diagnosed with GSM who were assigned to one of the three treatment groups for eight weeks. The primary outcome measured was the change in the Vaginal Health Index (VHI) score, while secondary outcomes included changes in the Female Sexual Distress Scale-Revised (FSDS-R) and the Menopause Rating Scale (MRS). Results indicated statistically significant improvements in VHI scores and reductions in FSDS-R and MRS scores across all treatment groups. The findings suggest that both vaginal hyaluronic acid and oral probiotics may serve as effective non-hormonal alternatives for managing GSM, particularly for women who prefer to avoid hormone therapy.