Kno2 is a software company based in the United States, founded in 2010, that operates within the healthcare technology sector. The company specializes in addressing foundational infrastructure challenges in healthcare, particularly focusing on health information exchange and patient data access. In a response to the Centers for Medicare & Medicaid Services (CMS) regarding the Health Technology Ecosystem, Kno2 emphasizes the importance of establishing a robust infrastructure to facilitate effective provider-to-provider communication and improve patient care quality. The company advocates for universal participation in the Trusted Exchange Framework and Common Agreement (TEFCA) among Medicare and Medicaid providers, highlighting the need for clear technical standards and financial support to overcome existing barriers. Kno2's insights reflect a commitment to enhancing connectivity in healthcare, particularly for vulnerable populations with complex chronic conditions, and addressing social determinants of health through comprehensive data sharing. The company employs a workforce of 11 to 50 individuals and reported revenue of approximately $30 million.