This guide outlines the alignment of the Lepide Data Security Platform with Microsoft 365 Copilot to enhance organizational productivity while addressing security and compliance risks. It presents a two-phase strategy for alignment: Pre-Deployment and Post-Deployment. The Pre-Deployment phase focuses on securing the environment before Copilot is enabled, which includes identifying and classifying sensitive data, remediating excessive permissions, cleaning up inactive accounts, and enforcing password compliance. The aim is to minimize the attack surface and ensure a controlled data environment. The Post-Deployment phase emphasizes ongoing protection during Copilot usage, involving monitoring access, detecting anomalous behavior, reviewing searches, and enforcing sensitivity labeling. This continuous monitoring allows organizations to respond rapidly to security incidents, ensuring the secure use of AI. The guide emphasizes enhanced data visibility, stronger access governance, proactive threat detection, and a sustainable compliance posture, enabling organizations to adopt Microsoft 365 Copilot confidently while maintaining data security.