Participant-Centered Support Model in GLP-1 Trials

This case study outlines the participant-centered support model developed by MRN to enhance retention in GLP-1 clinical trials. It addresses the challenges faced by participants, including side effects and lifestyle adjustments that contribute to high dropout rates. The study emphasizes the importance of providing consistent, one-on-one guidance from trained Patient Navigators via telemedicine, which aids in managing physical symptoms and mental health. The model has shown improved participant retention rates, better symptom management, and enhanced communication between sites and investigators. Additionally, the case study discusses the planning for Phase 3 studies, which will incorporate home trial support visits and continued remote guidance. The approach aims to remain adaptable to local cultural and regulatory factors while ensuring participant-focused care. Overall, the findings suggest that specialized support can significantly influence trial continuity and data quality, shaping future GLP-1 research.