Flow Cytometry Capabilities in Clinical Trials

This whitepaper details the capabilities and applications of flow cytometry in clinical trials. Flow cytometry is a technique used to measure various properties of individual cells, including gene and protein expression, chemical properties, and DNA content. It enhances the analysis of rare cells and allows for rapid examination of thousands of cells per second. The document outlines the operational principles of flow cytometry, including the use of laser beams and fluorescent probes to gather detailed cellular information. It also discusses the historical context of flow cytometry, its clinical applications since the 1980s, and its significance in oncology, particularly for monitoring blood cancers and assessing treatment effects. Additionally, the paper highlights the role of flow cytometry in measuring pharmacodynamics endpoints and immune system status, emphasizing its utility in various therapeutic areas such as oncology, infectious diseases, and autoimmune disorders. Medpace's expertise in flow cytometry and its application in global clinical trials is also presented.