This document is a technical report detailing the objectives and operations of the CMS Alliance to Modernize Healthcare, specifically through the Health Federally Funded Research and Development Center (Health FFRDC). It outlines MITRE's role in improving health and well-being by empowering patients, addressing root causes of diseases, and enhancing health systems. The report describes how MITRE collaborates with the Department of Health and Human Services (HHS) to provide objective support for confidential activities while maintaining a conflict-free stance as a not-for-profit organization. It emphasizes the importance of data science and technology in addressing urgent health challenges and highlights the strategic gaps filled by MITRE between the private sector and government. The report also discusses various initiatives aimed at enabling informed policy decisions, empowering patients and clinicians, advancing chronic disease research, and improving access to life-saving medicine. Additionally, it presents MITRE's approach to research and development, focusing on systems thinking, data-driven insights, and agility in meeting HHS's evolving needs.