This guide outlines best practices for implementing a proactive approach to API security. It emphasizes the importance of maintaining an accurate API inventory as a foundational step in securing APIs, as many organizations struggle to account for all their APIs. The document details the phases involved in building an API inventory, including pre-runtime and runtime protections. It suggests that organizations should embed a cataloging process into the API development lifecycle and continuously monitor API usage to identify unauthorized behavior. The guide also lists key focus areas for testing APIs, such as encryption, authentication, input validation, and rate limiting. Additionally, it recommends adopting strong authentication mechanisms, enforcing least-privilege access, and validating incoming data to mitigate risks. By following these practices, organizations can enhance their API security posture and reduce vulnerabilities, ultimately supporting business resilience.