Weight Maintenance Strategies After GLP-1 Discontinuation

This white paper discusses the challenges of maintaining weight loss after the discontinuation of GLP-1 medications, which are known for their effectiveness in weight management. It highlights findings from the Omada Insights Lab, which analyzed weight changes in 816 members without diabetes who participated in the GLP-1 Care Track. The analysis revealed that many individuals experience significant weight regain after stopping GLP-1 therapy, with studies indicating that up to 67% of weight lost may be regained within a year. The paper emphasizes the importance of lifestyle support during this transition, suggesting that programs like Omada can aid in weight maintenance post-discontinuation. Key findings include that 63.2% of Omada members maintained or lost weight at the 12-month mark after GLP-1 discontinuation, with average weight changes of 0.8%, 0.03%, and 0.6% at 12, 6, and 9 months respectively. The paper concludes by advocating for collaborative decision-making regarding the duration of GLP-1 therapy and the role of lifestyle support in achieving sustained health outcomes.