This guide outlines the evolution of enterprise applications from traditional on-premise deployments to cloud-native architectures. It discusses the fundamental goals of enterprise applications, emphasizing the importance of availability, durability, reliability, and resiliency. The document details the design principles necessary for business continuity and security in cloud environments, including implementing a strong identity foundation and automating security best practices. Additionally, it highlights the significance of agility, performance efficiency, and cost optimization in cloud-native applications. The guide emphasizes the need for organizations to adapt rapidly to market changes, improve innovation, and learn from operational failures. It also addresses the importance of monitoring and optimizing workloads to ensure efficient resource use and cost management. This comprehensive framework aims to assist organizations in leveraging cloud-native technologies effectively to achieve their business objectives.