Optimizing Site Activation to Accelerate Clinical Trials

This white paper discusses the challenges faced by the biopharmaceutical industry in clinical trial site activation. It outlines how increasing complexity in studies, geographic shifts, and slower site contracting processes have led to prolonged site activation cycle times, which have increased by two months from 2017 to 2023. The paper presents strategies for drug developers to optimize site engagement, leverage advanced technologies, and streamline contract negotiations to improve trial efficiency and accelerate the delivery of treatments. Solutions include reducing points of contact for site engagement, utilizing AI and machine learning for site selection, and employing analytics to monitor site activation progress. A case study illustrates the effectiveness of these strategies, showing a 25-percentage point improvement in on-time site activation and a 15 percentage point increase in subject enrollment performance. The paper emphasizes the importance of implementing proven solutions to address the growing challenges in clinical trial site activation.