Customized Prospective Biospecimen Collection Case Study

This case study outlines a customized prospective biospecimen collection aimed at developing a blood-based liquid biopsy diagnostic for colorectal cancer (CRC). The objective was to create a rapid blood test sensitive to pre-cancerous lesions and early-stage CRC, which could enhance patient outcomes. The study required the collection of biospecimens from a large cohort of 700 subjects within a year, adhering to specific subject entry requirements and logistical constraints. Precision for Medicine implemented a biospecimen collection strategy utilizing a network of over 150 collection sites, ensuring ethical sourcing and compliance with client standards. Key actions included identifying optimal collection sites, engaging with site personnel, and managing logistics for specimen shipping. The results demonstrated rapid enrollment and specimen turnaround, achieving the target of 700 subjects and maintaining low screen failure rates. The study emphasizes the importance of collaboration and adherence to strict protocols in complex biospecimen collection processes.