Comparability of In-line and At-line Variable Pathlength Technology for Concentration Monitoring

This white paper evaluates the performance of the CTech FlowVPX and SoloVPE PLUS Systems in monitoring concentrations of monoclonal antibodies and antibody-drug conjugates during tangential flow filtration processes. It highlights the advantages of real-time monitoring over traditional off-line sampling methods, demonstrating improved accuracy and potential yield enhancements. The study also discusses the impact of variable pathlength technology and scatter correction settings on measurement rel