This document is a guide detailing the Roche Group's Safety, Security, Health, and Environmental Protection (SHE) goals for the period 2026–2029. It outlines the development process of these goals, which are synchronized with Roche's internal Sustainability Strategy and external compliance frameworks. The document emphasizes the importance of aligning with the Corporate Sustainability Reporting Directive (CSRD) and internationally recognized standards such as ISO 14001 and ISO 45001. The SHE goals are designed to address critical sustainability risks and are informed by benchmarking against industry peers. The guide further elaborates on the twelve specific SHE goals, including environmental targets aimed at reducing the organization's ecological footprint, enhancing product sustainability, and promoting employee health and safety. The goals also align with several United Nations Sustainable Development Goals (SDGs), reflecting Roche's commitment to a sustainable future. The document concludes with insights into the socialization of these goals within the organization, highlighting stakeholder engagement efforts.