This solution brief outlines Rubrik's approach to achieving end-to-end cyber resilience for Microsoft 365. It details how Rubrik integrates immutable data protection, advanced recovery orchestration, and proactive data security posture management on a unified platform. The document describes the importance of addressing resilience gaps that can arise from relying solely on native tools. It emphasizes the need for organizations to implement air-gapped security and orchestrated recovery capabilities to maintain business continuity. Additionally, the brief presents a case study of UC Irvine Health, which adopted Rubrik's solutions to enhance its cyber resilience and streamline data recovery processes. The organization prioritized patient safety and improved its preparedness for cybersecurity events through regular exercises and a unified data protection strategy. The document concludes by highlighting the benefits of Rubrik's platform in supporting organizations' data integrity and availability against cyber threats.