CYP2D6 Drug–Drug–Gene Interaction Network Development

This research article presents a comprehensive physiologically-based pharmacokinetic (PBPK) modeling network for CYP2D6 drug-drug-gene interactions (DDGIs). It explores the complexities of DDGIs, offering insights into clinical dosing strategies and drug development. The study highlights the predictive performance of the network, which includes 23 compounds and various CYP2D6 interactions, facilitating informed clinical decisions and enhancing precision medicine.