This document is a guide detailing the SafeEx Index 100:20 framework, which aims to transition hazardous industries from traditional, high-cost inspection processes to a more efficient, data-driven model. The framework outlines a phased approach to reduce the inspection workload from 100% to an optimized 20%, thereby enhancing workplace safety while significantly lowering operational expenditures (OPEX). The guide describes four phases: Phase 0 focuses on manual processes with Repair Priority identification; Phase 1 introduces a digital foundation and integrity of the hazardous area equipment (HAE) register; Phase 2 emphasizes strategic optimization and scope reduction through expert monitoring; and Phase 3 implements continuous supervision by skilled personnel to ensure compliance and safety. Each phase is designed to progressively decrease the inspection burden while improving safety and compliance with IEC and ISO standards. The document emphasizes the importance of real-time data integration and expert oversight to achieve long-term operational efficiency.