Chromatography Consultation Tools for Process Intensification

This document is a technical report that outlines the use of chromatography consultation tools aimed at enhancing process intensification (PI) in biomanufacturing, particularly for downstream processing (DSP). It describes various methodologies for intensifying purification workflows, emphasizing the importance of selecting the appropriate chromatography media and methods to achieve productivity gains. The report details different levels of intensification, from simple rapid cycling chromatography to more complex multi-column chromatography processes. It also introduces two specific tools developed by Sartorius: the Capture Intensifier Application and the Expert Chromatography Intensifier Tool (ExCIT). These tools assist users in modeling and evaluating cost savings and productivity gains associated with different chromatography strategies before laboratory implementation. The document highlights the significance of process modeling tools in ensuring that the chosen intensification approach aligns with production constraints and efficiency goals, ultimately supporting informed decision-making in biopharmaceutical manufacturing.