Proof of Concept for Connected Downstream Process

This research article explores the challenges and innovations in biomanufacturing, focusing on protein-based therapeutics and the implementation of connected downstream processes. It highlights process intensification technologies, including rapid-cycling chromatography and single-pass tangential-flow filtration, to improve productivity and efficiency in bioprocessing. The study presents a proof-of-concept for a fully connected downstream process, showcasing its potential benefits for the biopha