This guide outlines the key differences between the Cybersecurity Maturity Model Certification (CMMC) and the Federal Risk and Authorization Management Program (FedRAMP). It details the specific compliance requirements for U.S. Department of Defense (DoD) contractors and subcontractors in the Defense Industrial Base (DIB) regarding Controlled Unclassified Information (CUI) and Federal Contract Information (FCI). The guide explains the various compliance levels associated with CMMC, which include Level 1: Foundational, Level 2: Advanced, and Level 3: Expert, along with the relevant NIST SP 800-171 practices. It also describes FedRAMP's applicability to cloud service providers (CSPs) serving federal agencies, detailing the impact levels of Low, Moderate, and High, as well as the NIST SP 800-53 Rev 5 standards. The document provides guidance on when to choose CMMC or FedRAMP based on organizational needs and data handling requirements.