This guide examines the evolving landscape of supply chain management in 2025, focusing on five key trends that are gaining traction and a few that are underperforming. It outlines how organizations are moving beyond theoretical discussions about AI, digitalization, and resiliency to practical applications that enhance decision-making and operational efficiency. The document details the shift towards real-time execution, the critical nature of scenario planning, and the increasing maturity of Sales and Operations Planning (S&OP) and Integrated Business Planning (IBP) processes. Additionally, it discusses the diminishing centrality of ERP systems in planning and emphasizes the importance of embedding AI into daily operations. The guide aims to assist supply chain leaders in identifying effective strategies while avoiding investments in initiatives that do not yield results. By focusing on evidence-based planning and execution, organizations can better navigate the complexities of today's supply chain environment.