Compensation of Topography Variability in MALDI-TOF MS

This research article discusses the impact of sample topography variability on mass resolution and accuracy in MALDI-TOF MS. It highlights the effectiveness of lock mass correction in compensating for these variations, showcasing applications in oligonucleotides, protein profiling, and imaging. The study demonstrates how lock mass correction can enhance mass accuracy and resolution, addressing challenges posed by spatial distribution in sample analysis.