Detection of PFAS in Aqueous Samples Using MALDI-TOF Mass Spectrometry

This technical report presents a method for the detection of per- and polyfluoroalkyl substances (PFAS) in aqueous samples utilizing a benchtop linear MALDI-TOF mass spectrometer. The report outlines the persistent nature of PFAS as environmental contaminants and their associated health risks, including links to cancer and hormone disruption. The developed method is cost-effective and requires minimal sample preparation, allowing for rapid analysis of PFAS in various water samples. The report details the sample preparation process, including the use of specific matrices for optimal results, and provides limits of detection for representative PFAS compounds. Additionally, it discusses the analysis of bottled and pond water samples, highlighting the presence of PFAS in some samples. The findings indicate the method's applicability in environmental research and monitoring laboratories, emphasizing its robustness and ease of integration into existing laboratory setups.