PFAS Analysis Method Evaluation Using LCMS-8065XE

This technical report evaluates the performance of the LCMS-8065XE for the analysis of per- and polyfluoroalkyl substances (PFAS) in accordance with EPA Method 1633A. The report outlines the methodology for analyzing 40 native PFAS target compounds using extracted internal standards (EIS) and non-extracted internal standards (NIS). It details the preparation of stock standards, calibration curves, and the extraction process. The study emphasizes the importance of calibration stability and demonstrates the method's suitability for routine PFAS monitoring. The results indicate that the LCMS-8065XE achieved significantly lower limits of quantification compared to the EPA Method 1633A requirements, with robust performance across numerous injections. The report also discusses the chromatographic separation of PFAS from potential interferences, such as cholic acids, ensuring compliance with analytical standards. Overall, the findings support the reliability of the LCMS-8065XE for environmental and biological PFAS determinations.