The document is a guide that addresses the evolving role of Chief Information Security Officers (CISOs) in the context of increasing threats and the integration of artificial intelligence (AI) in security practices. It outlines the challenges faced by CISOs, including budget constraints, workforce development, and the need for executive support. The guide is based on a survey of 650 CISOs worldwide, providing insights into their adaptation strategies. It emphasizes the importance of data-driven approaches, human-centric leadership, and innovation in achieving digital resilience. Additionally, the guide presents five key considerations for CISOs to enhance their organizations' resilience, such as leveraging AI tools, collaborating with C-suite peers, and translating security benefits into business language. The document aims to empower CISOs to navigate their responsibilities effectively and champion resilience in the AI era.