Thermal Analysis Techniques in Pharmaceuticals

This technical report provides an overview of thermal analysis techniques used in the pharmaceutical industry, specifically focusing on Thermogravimetry (TGA), Differential Scanning Calorimetry (DSC), and Sorption Analysis (SA). It outlines the significance of these methods in ensuring the quality and stability of pharmaceutical products. The report discusses the importance of analyzing raw materials during incoming goods inspection and highlights the analytical tasks involved in the development of new active ingredients. It details how TGA measures mass changes in samples under controlled conditions, providing insights into thermal stability and material composition. Additionally, it explains the role of DSC in determining heat flow and material parameters such as melting temperature and compatibility. The report also emphasizes the relevance of sorption analysis in understanding moisture interactions and their effects on material stability. Overall, the document serves as a comprehensive guide for professionals in the pharmaceutical sector seeking to apply thermal analysis methods in their processes.