This guide serves as a resource for system designers working with galvanically isolated systems, focusing on the design and implementation of digital isolators. It outlines the various families of digital isolators offered by Texas Instruments, including the ISO78xx, ISO67xx, ISO77xx, ISO73xx, and ISO71xx families, detailing their voltage ratings and applications. The document explains the fundamental operating principles of digital isolators, including edge-based and On-Off Keying (OOK) communication methods. It provides recommendations for the placement of isolators within system designs and offers guidelines for creating an electromagnetic compatible (EMC) circuit-board design. Additionally, the guide includes a selection guide for digital isolators, outlining parameters of interest and considerations for PCB design, such as material, layer stack, and routing techniques. The document is structured to assist designers in efficiently integrating digital isolators into their systems, ensuring reliable performance and compliance with design standards.