Exploring Hereditary Cancer on cBioPortal

This document is a guide focused on exploring hereditary cancer, particularly through the lens of the cBioPortal platform. It outlines the case of Dr. Myra Ortiz, an oncologist who reviews the genomic report of her patient, Monica, who has a variant in the CDKN2A gene, increasing her risk for hereditary melanoma. The guide discusses the significance of age in cancer diagnosis, noting that cancer is typically associated with older age due to the accumulation of genetic mutations over time. It provides instructions for using the cBioPortal to investigate the age of diagnosis for melanoma patients and the implications of CDKN2A mutations. Additionally, it prompts users to analyze data from the cBioPortal, including the median age of diagnosis and the distribution of ages among patients with CDKN2A mutations. The document emphasizes the importance of understanding genetic factors in cancer risk and encourages exploration of the data available on the cBioPortal.