This white paper provides a detailed applicability guide for the Trend Micro Cloud One platform in relation to PCI DSS 4.0 compliance. It begins with an executive summary and outlines the objectives of the paper, which include assisting customers in understanding how the Cloud One platform can support their PCI DSS compliance efforts. The document covers various components of the Cloud One platform, including workload security, endpoint security, file storage security, and network security, detailing their specific functionalities and contributions to meeting PCI DSS requirements. Additionally, it discusses the evaluation methodology for PCI controls and presents a summary of the overall PCI DSS 4.0 scoring. Each PCI requirement is addressed, explaining how the Cloud One platform supports compliance with each specific requirement, such as maintaining network security controls, protecting stored account data, and logging access to system components. The paper serves as a comprehensive resource for organizations seeking to leverage the Cloud One platform to achieve and maintain PCI DSS 4.0 compliance.